HCID 69053739, compound → HCID 57597584, compound

HRID 1786541Notes

Reaction equation

HRID 1786541 reaction equation
[CH:1]([NH:14][C:15](=[O:31])[N:16]([CH:18]1[CH2:22][CH2:21][N:20](C(=O)C2C=CC=CC=2)[CH2:19]1)[CH3:17])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[Pd]>[CH:1]([NH:14][C:15](=[O:31])[N:16]([CH3:17])[C@@H:18]1[CH2:22][CH2:21][NH:20][CH2:19]1)([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 1

HCID 69053739HCID 69053739, compound

Product 1

HCID 57597584HCID 57597584, compoundYield 116.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 3-benzhydryl-1-(1-benzoyl-pyrrolidin-3-yl)-1-methyl-urea (0.7 g, 1.75 mmol) in CH3OH (25 ml) was added Pd/C 20% (175 mg). The resulting slurry was hydrogenated at 50 psi for 24 hours. The catalyst was filtered through Celite and filtrate evaporated under reduced pressure to, give 0.63 g of desired product.

Workup

  1. filtrationThe catalyst was filtered through Celite and filtrate
  2. customevaporated under reduced pressure to,

Sources & evidence

ORD record
ord-189f5f3cf8bb43dca2e6b5ca20960bd3
Source dataset
uspto-grants-2009_03
Patent number
US07507760B2

Reaction notes

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