HCID 69053132, compound → HCID 57597579, compound

HRID 1786544Notes

Reaction equation

HRID 1786544 reaction equation
C([N:9]1[CH2:13][CH2:12][C@@H:11]([N:14]([CH3:31])[C:15](=[O:30])[CH2:16][N:17]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:10]1)(=O)C1C=CC=CC=1>CO.[Pd]>[C:24]1([N:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:16][C:15]([N:14]([CH3:31])[C@@H:11]2[CH2:12][CH2:13][NH:9][CH2:10]2)=[O:30])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 1

HCID 69053132HCID 69053132, compound

Product 1

HCID 57597579HCID 57597579, compoundYield 114.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of (R)—N-(1-benzoyl-pyrrolidin-3-yl)-2-diphenylamino-N-methyl-acetamide (0.68 g, 1.7 mmol) in CH3OH (30 ml) was added Pd/C 20% (170 mg). The resulting slurry was hydrogenated at 50 psi for 24 hours. The catalyst was filtered through Celite and filtrate evaporated under reduced pressure to give 0.6 g of desired product.

Workup

  1. filtrationThe catalyst was filtered through Celite and filtrate
  2. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-e56469efe4574f2b8684abbf187dfa1c
Source dataset
uspto-grants-2009_03
Patent number
US07507760B2

Reaction notes

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