HCID 86599801, compound → HCID 57597558, compound

HRID 1786547Notes

Reaction equation

HRID 1786547 reaction equation
C([N:9]1[CH2:13][CH2:12][C@@H:11]([N:14]([CH3:31])[CH2:15][C:16]([N:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:17])[CH2:10]1)(=O)C1C=CC=CC=1>CO.[Pd]>[CH3:31][N:14]([C@@H:11]1[CH2:12][CH2:13][NH:9][CH2:10]1)[CH2:15][C:16]([N:18]([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:17]

Participants

4

Reactant 1

HCID 86599801HCID 86599801, compound

Product 1

HCID 57597558HCID 57597558, compoundYield 95.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of (R)-2-[(1-benzoyl-pyrrolidin-3-yl)-methyl-amino]-N,N-diphenyl acetamide(0.68 g, 1.70 mmol) in CH3OH (30 ml) was added Pd/C 20% (170 mg). The resulting slurry was hydrogenated at 50 psi for 24 hours. The catalyst was filtered through Celite and filtrate evaporated under reduced pressure to give 0.5 g of desired product.

Workup

  1. filtrationThe catalyst was filtered through Celite and filtrate
  2. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-a1bf7b07a6e84b91be3f4ef0d347f994
Source dataset
uspto-grants-2009_03
Patent number
US07507760B2

Reaction notes

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