反应详情

To the solution of (1-benzhydryl-2-oxo-pyrrollidin-3-yl)-carbamic acid tert-butyl ester (41) (1.2 g, 3.26 mmol) in CH2Cl2 (20 ml) was added CF3CO2H (8 ml). The resulting mixture was stirred under nitrogen at room temperature overnight. The reaction was then concentrated under reduced pressure. The residue was dissolved in ethyl acetate and washed with saturated sodium hydrogen carbonate (20 ml). The organic was dried over MgSO4 and evaporated to dryness. The resulting residue was purified by column chromatography using CH2Cl2: MeOH (10:1) to give the desired product in 97% yield.

1. concentrationThe reaction was then concentrated under reduced pressure
2. dissolutionThe residue was dissolved in ethyl acetate
3. washwashed with saturated sodium hydrogen carbonate (20 ml)
4. dry with materialThe organic was dried over MgSO4
5. customevaporated to dryness
6. customThe resulting residue was purified by column chromatography