反应详情

A mixture of 4-[4-(5-methoxy-pyridin-2-yl)-phenoxymethyl]-5-methyl-furan-2-carboxylic acid methyl ester (52) (70 mg) and 1M aqueous lithium hydroxide (1 mL) in tetrahydrofuran/methanol (2:1 by volume) (12 mL) was stirred at room temperature for 16 hours. The reaction mixture was acidified to between pH6 and pH7, and partitioned between ethyl acetate and water. The organic phase was separated, washed with brine and dried (MgSO4). After removal of the solvent, the residue was purified by HPLC. Compound 53 was obtained as a solid (2.5 mg). LC/MS System A: Rt=2.90 mins, m/z (ES+) 340 ((M+H) for C19H17NO5).

1. custompartitioned between ethyl acetate and water
2. customThe organic phase was separated
3. washwashed with brine
4. dry with materialdried (MgSO4)
5. customAfter removal of the solvent
6. customthe residue was purified by HPLC