HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1786668Generated: October 30, 2026
Hydrochloric Acid → 4-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one
https://huagongshe.com/reaction/1786668
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| Reactant | 2-(3-Methoxy-6-pyridin-4-yl-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester | HCID 67148857 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one | HCID 135687553 | 25.1% |
Reaction Steps
25 mg of 2-(3-Methoxy-6-pyridin-4-yl-pyridazin-4-yl) -indole-1-carboxylic acid tert-butyl ester, 7.4 mg trimethylchlorosilane and 11.3 mg KI dissolved in 1 ml of acetonitrile are stirred for 2 h at 60° C. Subsequently, 0.5 ml of a 4N solution of hydrochloric acid in dioxane is added and stirred for 2 h at room temperature. The solution is diluted into DMF/water and directly purified by HPLC on a RP18 column giving 4.5 mg 4-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07507734B2 |
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| Source dataset | uspto-grants-2009_03 |
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| ORD ID | ord-b550d42f4a41483788e567e509065321 |
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| Source note | uspto-grants-2009_03 |
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