反应详情

温度

60 °C

25 mg of 2-(3-Methoxy-6-pyridin-4-yl-pyridazin-4-yl) -indole-1-carboxylic acid tert-butyl ester, 7.4 mg trimethylchlorosilane and 11.3 mg KI dissolved in 1 ml of acetonitrile are stirred for 2 h at 60° C. Subsequently, 0.5 ml of a 4N solution of hydrochloric acid in dioxane is added and stirred for 2 h at room temperature. The solution is diluted into DMF/water and directly purified by HPLC on a RP18 column giving 4.5 mg 4-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one.

1. stirringstirred for 2 h at room temperature
2. customdirectly purified by HPLC on a RP18 column