1,4-Bis(bromomethyl)benzene → HCID 10128473, compound

HRID 1786780Notes

Reaction equation

HRID 1786780 reaction equation
[CH3:1][C:2]([C:4]1[C:9]([O:10][CH3:11])=[C:8]2[CH:12]=[CH:13][O:14][C:7]2=[CH:6][C:5]=1[OH:15])=[O:3].Br[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24]Br)=[CH:20][CH:19]=1>>[C:2]([C:4]1[C:5]([O:15][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([CH2:24][O:15][C:5]3[C:4]([C:2](=[O:3])[CH3:1])=[C:9]([O:10][CH3:11])[C:8]4[CH:12]=[CH:13][O:14][C:7]=4[CH:6]=3)=[CH:20][CH:19]=2)=[CH:6][C:7]2[O:14][CH:13]=[CH:12][C:8]=2[C:9]=1[O:10][CH3:11])(=[O:3])[CH3:1]

Participants

3

Reactant 2

HCID 693351,4-Bis(bromomethyl)benzeneHCID 3013891Ethanone, 1-(6-hydroxy-4-methoxy-5-benzofuranyl)-

Product 1

HCID 10128473HCID 10128473, compoundYield 8%

Procedure

The compound was prepared from visnaginone and α,α′-dibromo-p-xylene according to the General Procedure. Purification by flash chromatography eluting with ethyl acetate/cyclohexane (1:9 to 2:8) afforded the product (20 mg, 8%) as a white solid:

Workup

  1. customPurification by flash chromatography
  2. washeluting with ethyl acetate/cyclohexane (1:9 to 2:8)

Sources & evidence

ORD record
ord-5d52dd48d0d04788a0e69b29e66c6971
Source dataset
uspto-grants-2009_03
Patent number
US07507839B2

Reaction notes

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