HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methyl-4-((6-methylpyridin-3-yl)oxy)aniline → 5-methyl-N-{3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl}-5H-pyrrolo[3,2-d]pyrimidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methyl-4-((6-methylpyridin-3-yl)oxy)aniline | HCID 11424434 | — |
| Reactant | 4-Chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine | HCID 59424505 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 5-methyl-N-{3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl}-5H-pyrrolo[3,2-d]pyrimidin-4-amine | HCID 57597363 | 51.4% |
Reaction Steps
To a solution of 4-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine (100 mg) in 1-methyl-2-pyrrolidone (1.0 mL) was added 3-methyl-4-[(6-methylpyridin-3-yl)oxy]aniline (192 mg). The title compound (106 mg) was obtained as white powder crystals by the reaction in the same manner as in Example 39 (ii).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07507740B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-5ee2addd3ec74a60b158f1e5ea3cd0a9 |
| Source note | uspto-grants-2009_03 |