Hydrochloric Acid → HCID 57597313, compound

HRID 1786918Notes

Reaction equation

HRID 1786918 reaction equation
[N:1]1[C:6]2[CH:7]=[CH:8][NH:9][C:5]=2[C:4]([NH:10][C:11]2[CH:12]=[C:13]([CH:19]=[CH:20][CH:21]=2)[C:14]([O:16]CC)=[O:15])=[N:3][CH:2]=1.[OH-].[Na+].Cl>CO>[N:1]1[C:6]2[CH:7]=[CH:8][NH:9][C:5]=2[C:4]([NH:10][C:11]2[CH:12]=[C:13]([CH:19]=[CH:20][CH:21]=2)[C:14]([OH:16])=[O:15])=[N:3][CH:2]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57597372HCID 57597372, compound

Product 1

HCID 57597313HCID 57597313, compoundYield 102.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A mixture of ethyl 3-(5H-pyrrolo[3,2-d]pyrimidin-4-ylamino)benzoate (3.34 g), 1N aqueous sodium hydroxide solution (25 mL) and methanol (50 mL) was stirred overnight at room temperature. To the reaction mixture was added 1N hydrochloric acid (25 mL), and methanol was evaporated under reduced pressure. The precipitated crystals were collected by filtration and washed with water to give the title compound (3.09 g) as a pale-brown powder.

Workup

  1. customwas evaporated under reduced pressure
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-240d07a3cd4f4b5f82d57410f500c678
Source dataset
uspto-grants-2009_03
Patent number
US07507740B2

Reaction notes

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