Hydrochloric Acid → HCID 57597298, compound

HRID 1786927Notes

Reaction equation

HRID 1786927 reaction equation
[O:1]([C:8]1[CH:18]=[CH:17][C:16]([NH:19][C:20]2[C:21]3[NH:28][CH:27]=[CH:26][C:22]=3[N:23]=[CH:24][N:25]=2)=[CH:15][C:9]=1[C:10]([O:12]CC)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>CO>[O:1]([C:8]1[CH:18]=[CH:17][C:16]([NH:19][C:20]2[C:21]3[NH:28][CH:27]=[CH:26][C:22]=3[N:23]=[CH:24][N:25]=2)=[CH:15][C:9]=1[C:10]([OH:12])=[O:11])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57597231HCID 57597231, compound

Product 1

HCID 57597298HCID 57597298, compoundYield 92.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
60 °C

Procedure

A mixture of ethyl 2-phenoxy-5-(5H-pyrrolo[3,2-d]pyrimidin-4-ylamino)benzoate (899 mg), 1N aqueous sodium hydroxide solution (5 mL) and methanol (15 mL) was stirred at 60° C. for 1.5 hrs. To the reaction mixture was added 1N hydrochloric acid (5 mL), and methanol was evaporated under reduced pressure. The precipitated crystals were collected by filtration, and washed with water and acetone to give the title compound (768 mg) as a pale-brown powder.

Workup

  1. customwas evaporated under reduced pressure
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed with water and acetone

Sources & evidence

ORD record
ord-f8b70c4375f04973a2417d592922d457
Source dataset
uspto-grants-2009_03
Patent number
US07507740B2

Reaction notes

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