Phenylboronic Acid → HCID 23114300, compound

HRID 1787267Notes

Reaction equation

HRID 1787267 reaction equation
Br[C:2]1[C:19]([NH:20][C:21](=[O:27])[CH2:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[C:18]([CH3:28])[C:5]2[CH:6]([C:9]3[CH:14]=[CH:13][C:12]([CH:15]([CH3:17])[CH3:16])=[CH:11][CH:10]=3)[CH2:7][O:8][C:4]=2[C:3]=1[CH3:29].[C:30]1(B(O)O)[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>CCCCCC.C(OCC)(=O)C>[CH:15]([C:12]1[CH:11]=[CH:10][C:9]([CH:6]2[C:5]3[C:18]([CH3:28])=[C:19]([NH:20][C:21](=[O:27])[CH2:22][C:23]([CH3:25])([CH3:24])[CH3:26])[C:2]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)=[C:3]([CH3:29])[C:4]=3[O:8][CH2:7]2)=[CH:14][CH:13]=1)([CH3:16])[CH3:17]

Participants

4

Reactant 2

HCID 66827Phenylboronic AcidHCID 23113846HCID 23113846, compound

Product 1

HCID 23114300HCID 23114300, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using N-(6-bromo-3-(4-isopropylphenyl)-4,7-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethylbutanamide obtained in Example 87 and phenylboronic acid, the title compound was synthesized in the same manner as in Example 101. Yield: 42%. Melting point: 212-213° C. (hexane-ethyl acetate).

Sources & evidence

ORD record
ord-79a1f093871245b1b73b7d203f981f4f
Source dataset
uspto-grants-2009_03
Patent number
US07507841B2

Reaction notes

Loading…