3-Amino-1-propanol → HCID 23114403, compound

HRID 1787304Notes

Reaction equation

HRID 1787304 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[C:14]3[C:15]([CH3:35])=[C:16]([NH:26][C:27](=[O:34])OCC(Cl)(Cl)Cl)[C:17]([CH3:25])=[C:18]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[C:13]=3[O:12][CH2:11]2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[NH2:36][CH2:37][CH2:38][CH2:39][OH:40]>CCCCCC.C(OCC)(=O)C>[OH:40][CH2:39][CH2:38][CH2:37][NH:36][C:27]([NH:26][C:16]1[C:17]([CH3:25])=[C:18]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]2[O:12][CH2:11][CH:10]([C:7]3[CH:6]=[CH:5][C:4]([CH:1]([CH3:2])[CH3:3])=[CH:9][CH:8]=3)[C:14]=2[C:15]=1[CH3:35])=[O:34]

Participants

4

Reactant 2

HCID 90863-Amino-1-propanolHCID 86618062HCID 86618062, compound

Product 1

HCID 23114403HCID 23114403, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using 2,2,2-trichloroethyl (3-(4-isopropylphenyl)-4,6-dimethyl-7-phenyl-2,3-dihydro-1-benzofuran-5-yl)carbamate obtained in Example 142 and 3-amino-1-propanol, the title compound was synthesized in the same manner as in Example 143. Yield: 65%. Melting point: 145-146° C. (hexane-ethyl acetate).

Sources & evidence

ORD record
ord-8fc88dfe36404b12b66b013d683fbb5c
Source dataset
uspto-grants-2009_03
Patent number
US07507841B2

Reaction notes

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