3-Amino-1-propanol → HCID 23114232, compound

HRID 1787335Notes

Reaction equation

HRID 1787335 reaction equation
[C:1]([C:4]1[C:12]2[O:11][CH2:10][CH:9]([C:13]3[CH:18]=[CH:17][C:16]([CH:19]([CH3:21])[CH3:20])=[CH:15][CH:14]=3)[C:8]=2[C:7]([CH3:22])=[C:6]([NH:23][C:24](=[O:31])OCC(Cl)(Cl)Cl)[C:5]=1[CH3:32])(=[O:3])[CH3:2].[OH:33][CH2:34][CH2:35][CH2:36][NH2:37]>>[C:1]([C:4]1[C:12]2[O:11][CH2:10][CH:9]([C:13]3[CH:14]=[CH:15][C:16]([CH:19]([CH3:21])[CH3:20])=[CH:17][CH:18]=3)[C:8]=2[C:7]([CH3:22])=[C:6]([NH:23][C:24]([NH:37][CH2:36][CH2:35][CH2:34][OH:33])=[O:31])[C:5]=1[CH3:32])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 86618063HCID 86618063, compound

Product 1

HCID 23114232HCID 23114232, compoundYield 59%

Procedure

Using 2,2,2-trichloroethyl (7-acetyl-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)carbamate obtained in Example 206 and 3-hydroxypropylamine, the title compound was obtained in the same as manner as in Example 143. Yield: 59%.

Sources & evidence

ORD record
ord-2d9877c49aeb46139b99bfe0849b1864
Source dataset
uspto-grants-2009_03
Patent number
US07507841B2

Reaction notes

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