Pyrrolidine → HCID 23114360, compound

HRID 1787370Notes

Reaction equation

HRID 1787370 reaction equation
O[CH:2]1[C:6]2[C:7]([CH3:21])=[C:8]([NH:13][C:14](=[O:20])[CH2:15][C:16]([CH3:19])([CH3:18])[CH3:17])[C:9]([CH3:12])=[C:10]([CH3:11])[C:5]=2[O:4][C:3]1([CH3:23])[CH3:22].[NH:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1>C(OCC)(=O)C.CCCCCC>[CH3:17][C:16]([CH3:18])([CH3:19])[CH2:15][C:14]([NH:13][C:8]1[C:7]([CH3:21])=[C:6]([CH3:2])[C:5]2[O:4][C:3]([CH3:23])([CH3:22])[CH:11]([N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)[C:10]=2[C:9]=1[CH3:12])=[O:20]

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 23114218HCID 23114218, compound

Product 1

HCID 23114360HCID 23114360, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using N-(3-hydroxy-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethylbutanamide obtained in Example 234 and pyrrolidine, the title compound was synthesized in the same manner as in Example 297. Yield: 36%. Melting point: 197-198° C. (ethyl acetate-hexane). 1H-NMR (CDCl3) δ: 1.16 (9H, s), 1.23 (3H, s), 1.49 (3H, s), 1.58-1.72 (4H, m), 2.09 (3H, s), 2.13 (6H, s), 2.30 (2H, s), 2.48-2.80 (4H, m), 4.02 (1H, s), 6.55 (1H, br s).

Sources & evidence

ORD record
ord-1a98078a9a7541c8a82f984070e184ac
Source dataset
uspto-grants-2009_03
Patent number
US07507841B2

Reaction notes

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