Pyrrolidine → HCID 86612366, compound

HRID 1787374Notes

Reaction equation

[Br:1][C:2]1[C:10]2[O:9][C:8]([CH3:12])([CH3:11])[CH:7](O)[C:6]=2[C:5]([CH3:14])=[C:4]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[C:3]=1[CH3:23].[NH:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1>>[Br:1][C:2]1[C:10]2[O:9][C:8]([CH3:12])([CH3:11])[CH:7]([N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)[C:6]=2[C:5]([CH3:14])=[C:4]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:19])([CH3:21])[CH3:20])[C:3]=1[CH3:23]

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 86612364HCID 86612364, compound

Product 1

HCID 86612366HCID 86612366, compoundYield 43%

Procedure

Using tert-butyl (7-bromo-3-hydroxy-2,2,4,6-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)carbamate obtained in Example 236 and pyrrolidine, the title compound was synthesized in the same manner as in Example 297.

Sources & evidence

ORD record: ord-62c790db8db3440d9e9cacf986bbb711
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07507841B2

Reaction notes

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