{2-[3-(3-Bromo-phenyl)-3-oxo-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester → 4-(3-Bromo-phenyl)-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Participants

Reaction Steps

) The title compound was prepared from the above described {2-[3-(3-bromo-phenyl)-3-oxo-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (1.152 g, 2.30 mmol) and TFA (10 mL) according to general procedure I step 2. Obtained as a light yellow solid (0.730 g, 82%). MS (ISP) 383.0 [(M+H)+] and 385.0 [(M+2+H)+].

Provenance & Evidence