{2-[3-(3-Bromo-phenyl)-3-oxo-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester → HCID 67361818, compound

HRID 1787418Notes

Reaction equation

HRID 1787418 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=1[NH:18][C:19](=[O:30])[CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([Br:29])[CH:24]=1)=O)(C)(C)C>C(O)(C(F)(F)F)=O>[Br:29][C:25]1[CH:24]=[C:23]([C:21]2[CH2:20][C:19](=[O:30])[NH:18][C:9]3[CH:10]=[C:11]([C:14]([F:17])([F:16])[F:15])[CH:12]=[CH:13][C:8]=3[N:7]=2)[CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 1

HCID 86623847{2-[3-(3-Bromo-phenyl)-3-oxo-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester

Product 1

HCID 67361818HCID 67361818, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

) The title compound was prepared from the above described {2-[3-(3-bromo-phenyl)-3-oxo-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (1.152 g, 2.30 mmol) and TFA (10 mL) according to general procedure I step 2. Obtained as a light yellow solid (0.730 g, 82%). MS (ISP) 383.0 [(M+H)+] and 385.0 [(M+2+H)+].

Sources & evidence

ORD record
ord-daae4e2bc2b94444b3f4b9cd9502bddc
Source dataset
uspto-grants-2009_03
Patent number
US07511033B2

Reaction notes

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