Trifluoroacetic acid → HCID 67362381, compound

HRID 1787420Notes

Reaction equation

HRID 1787420 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])=[CH:10][C:9]=1[NH:21][C:22](=[O:33])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([Br:32])[CH:27]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>>[Br:32][C:28]1[CH:27]=[C:26]([C:24]2[CH2:23][C:22](=[O:33])[NH:21][C:9]3[CH:10]=[C:11]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=4[F:20])[CH:12]=[CH:13][C:8]=3[N:7]=2)[CH:31]=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86623849HCID 86623849, compound

Product 1

HCID 67362381HCID 67362381, compound

Procedure

) The title compound was prepared from the above described {3-[3-(3-bromo-phenyl)-3-oxo-propionylamino]-2′-fluoro-biphenyl-4-yl}-carbamic acid tert-butyl ester (2.15 g, 4.076 mmol, 90% purity) and TFA (15 mL) according to general procedure I step 2. Obtained as a light yellow solid (1.25 g, 75%). MS (ISP) 409.0 [(M+H)+] and 411.0 [(M+2+H)+].

Sources & evidence

ORD record
ord-d0c4299669e74c4990e962fecdbce022
Source dataset
uspto-grants-2009_03
Patent number
US07511033B2

Reaction notes

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