Trifluoroacetic acid → HCID 67361226, compound

HRID 1787423Notes

Reaction equation

HRID 1787423 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([NH:14][CH2:15][CH:16]([CH3:18])[CH3:17])[C:11]([C:19]([F:22])([F:21])[F:20])=[CH:10][C:9]=1[NH:23][C:24](=[O:35])[CH2:25][C:26]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([Br:34])[CH:29]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:34][C:30]1[CH:29]=[C:28]([C:26]2[CH2:25][C:24](=[O:35])[NH:23][C:9]3[CH:10]=[C:11]([C:19]([F:22])([F:21])[F:20])[C:12]([NH:14][CH2:15][CH:16]([CH3:17])[CH3:18])=[CH:13][C:8]=3[N:7]=2)[CH:33]=[CH:32][CH:31]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86623852HCID 86623852, compound

Product 1

HCID 67361226HCID 67361226, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

) The title compound was prepared from the above described {2-[3-(3-bromo-phenyl)-3-oxo-propionylamino]-5-isobutylamino-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (1.03 g, 1.8 mmol) and TFA (7 mL) in DCM (20 mL) according to general procedure I step 2. Obtained as a light yellow solid (0.75 g, 92%). MS (ISP) 454.3 [(M+H)+]; mp 217° C. (dec).

Sources & evidence

ORD record
ord-3836a7a608774b60ad153350925398f8
Source dataset
uspto-grants-2009_03
Patent number
US07511033B2

Reaction notes

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