Trifluoroacetic acid → 3'-(4-Oxo-7-trifluoromethyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-biphenyl-3-sulfonic acid amide

HRID 1787431Notes

Reaction equation

HRID 1787431 reaction equation
C([NH:5][S:6]([C:9]1[CH:10]=[C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]3[CH2:22][C:23](=[O:36])[NH:24][C:25]4[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[CH:28][C:26]=4[N:27]=3)[CH:16]=2)[CH:12]=[CH:13][CH:14]=1)(=[O:8])=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>>[O:36]=[C:23]1[CH2:22][C:21]([C:17]2[CH:16]=[C:15]([C:11]3[CH:12]=[CH:13][CH:14]=[C:9]([S:6]([NH2:5])(=[O:7])=[O:8])[CH:10]=3)[CH:20]=[CH:19][CH:18]=2)=[N:27][C:26]2[CH:28]=[CH:29][C:30]([C:32]([F:34])([F:35])[F:33])=[CH:31][C:25]=2[NH:24]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 250500173'-(4-Oxo-7-trifluoromethyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-biphenyl-3-sulfonic acid tert-butylamide

Product 1

HCID 250523263'-(4-Oxo-7-trifluoromethyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-biphenyl-3-sulfonic acid amide

Procedure

The title compound was prepared from 3′-(4-oxo-7-trifluoromethyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-biphenyl-3-sulfonic acid tert-butylamide (Example 4) (177 mg, 0.3 mmol) and TFA (5 mL) according to the general procedure I step 2. Obtained as an off-white solid (122 mg, 77%). MS (ISP) 460.0 [(M+H)+]; mp 170° C. (dec).

Sources & evidence

ORD record
ord-2181e5f559bc44a69f7f82f40bac6fb8
Source dataset
uspto-grants-2009_03
Patent number
US07511033B2

Reaction notes

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