Trifluoroacetic acid → HCID 25052162, compound

HRID 1787434Notes

Reaction equation

C([NH:5][S:6]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]3[CH2:22][C:23](=[O:39])[NH:24][C:25]4[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[C:29]([O:36][CH2:37][CH3:38])=[CH:28][C:26]=4[N:27]=3)[CH:16]=2)=[CH:11][CH:10]=1)(=[O:8])=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>>[CH2:37]([O:36][C:29]1[C:30]([C:32]([F:35])([F:34])[F:33])=[CH:31][C:25]2[NH:24][C:23](=[O:39])[CH2:22][C:21]([C:17]3[CH:16]=[C:15]([C:12]4[CH:11]=[CH:10][C:9]([S:6]([NH2:5])(=[O:7])=[O:8])=[CH:14][CH:13]=4)[CH:20]=[CH:19][CH:18]=3)=[N:27][C:26]=2[CH:28]=1)[CH3:38]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 25052325HCID 25052325, compound

Product 1

HCID 25052162HCID 25052162, compound

Procedure

The title compound was prepared from 3′-(8-ethoxy-4-oxo-7-trifluoromethyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-biphenyl-4-sulfonic acid tert-butylamide (Example 7) (205 mg, 0.4 mmol) and TFA (5 mL) according to the general procedure I step 2. Obtained as an off-white solid (94 mg, 51%). MS (ISP) 503.8 [(M+H)+]; mp 245-250° C. (dec).

Sources & evidence

ORD record: ord-602ad76da3a54db6ad3823f5f4cd2ec0
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07511033B2

Reaction notes

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