Trifluoroacetic acid → HCID 25049859, compound

HRID 1787436Notes

Reaction equation

C([NH:5][S:6]([C:9]1[CH:10]=[C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]3[CH2:22][C:23](=[O:39])[NH:24][C:25]4[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[C:29]([N:36]([CH3:38])[CH3:37])=[CH:28][C:26]=4[N:27]=3)[CH:16]=2)[CH:12]=[CH:13][CH:14]=1)(=[O:8])=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>>[CH3:37][N:36]([CH3:38])[C:29]1[C:30]([C:32]([F:35])([F:33])[F:34])=[CH:31][C:25]2[NH:24][C:23](=[O:39])[CH2:22][C:21]([C:17]3[CH:16]=[C:15]([C:11]4[CH:12]=[CH:13][CH:14]=[C:9]([S:6]([NH2:5])(=[O:7])=[O:8])[CH:10]=4)[CH:20]=[CH:19][CH:18]=3)=[N:27][C:26]=2[CH:28]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 67362097HCID 67362097, compound

Product 1

HCID 25049859HCID 25049859, compound

Procedure

) The title compound was prepared from the above described 3′-(8-dimethylamino-4-oxo-7-trifluoromethyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-biphenyl-3-sulfonic acid tert-butylamide (130 mg) and TFA (3 mL) according to the general procedure I step 2. Obtained as a light yellow solid (40 mg, 16%). MS (ISN) 501.4 [(M−H)−]; mp 258° C. (dec).

Sources & evidence

ORD record: ord-ad04d136af4a4590bc2c869e4bd85f7e
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07511033B2

Reaction notes

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