Trifluoroacetic acid → HCID 25052323, compound

HRID 1787441Notes

Reaction equation

C([NH:5][S:6]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]3[CH2:22][C:23](=[O:41])[NH:24][C:25]4[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[C:29]([NH:36][CH2:37][CH:38]([CH3:40])[CH3:39])=[CH:28][C:26]=4[N:27]=3)[CH:16]=2)=[CH:11][CH:10]=1)(=[O:8])=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>>[CH2:37]([NH:36][C:29]1[C:30]([C:32]([F:33])([F:34])[F:35])=[CH:31][C:25]2[NH:24][C:23](=[O:41])[CH2:22][C:21]([C:17]3[CH:16]=[C:15]([C:12]4[CH:11]=[CH:10][C:9]([S:6]([NH2:5])(=[O:8])=[O:7])=[CH:14][CH:13]=4)[CH:20]=[CH:19][CH:18]=3)=[N:27][C:26]=2[CH:28]=1)[CH:38]([CH3:40])[CH3:39]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 67362313HCID 67362313, compound

Product 1

HCID 25052323HCID 25052323, compound

Procedure

) The title compound was prepared from the above described 3′-(8-isobutylamino-4-oxo-7-trifluoromethyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-biphenyl-4-sulfonic acid tert-butylamide (275 mg) and TFA (6 mL) according to the general procedure I step 2. Obtained as a yellow solid (126 mg, 47%). MS (ISN) 529.4 [(M−H)−]; mp 251° C. (dec).

Sources & evidence

ORD record: ord-30cd979e920349b6ae76ec83c97f3609
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07511033B2

Reaction notes

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