Bicarbonate Ion → tert-Butyl 6-bromo-3',6'-dihydro-2,4'-bipyridine-1'(2'H)-carboxylate

HRID 178748Notes

Reaction equation

HRID 178748 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([C:8]2([OH:21])[CH2:9][CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]2)[n:7]1.[Na+:27].[OH:28][C:29](=[O:30])[O-:31].[P:22]([Cl:23])([Cl:24])([Cl:25])=[O:26].[cH:32]1[cH:33][cH:34][n:35][cH:36][cH:37]1>>[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([C:8]2=[CH:9][CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]2)[n:7]1

Participants

6

Reactant 5

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 1049PyridineHCID 24813Phosphorus oxychlorideHCID 86614831tert-Butyl 4-(6-bromopyridin-2-yl)-4-hydroxypiperidine-1-carboxylate

Product 1

HCID 86614830tert-Butyl 6-bromo-3',6'-dihydro-2,4'-bipyridine-1'(2'H)-carboxylate

Sources & evidence

ORD record
ord-913b3765388f4f73accfbdb8f5787d12
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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