HCID 10003096, compound → HCID 9979591, compound

HRID 1787489Notes

Reaction equation

HRID 1787489 reaction equation
[C:1]1([C@@H:7]([NH:9][C:10]2[N:15]=[C:14]([N:16]3[C:20]4[CH:21]=[CH:22][C:23]([NH:25][C:26](=O)[C:27]5[CH:32]=[CH:31][CH:30]=[N:29][CH:28]=5)=[CH:24][C:19]=4[N:18]=[CH:17]3)[CH:13]=[N:12][CH:11]=2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[C:1]1([C@@H:7]([NH:9][C:10]2[N:15]=[C:14]([N:16]3[C:20]4[CH:21]=[CH:22][C:23]([NH:25][CH2:26][C:27]5[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=5)=[CH:24][C:19]=4[N:18]=[CH:17]3)[CH:13]=[N:12][CH:11]=2)[CH3:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 10003096HCID 10003096, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 9979591HCID 9979591, compoundYield 24%

Procedure

In a procedure analogous to example 46, reaction of N-[1-(6-{[(1S)-1-phenylethyl]amino}pyrazin-2-yl)-1H-benzimidazol-5-yl]nicotinamide (33 mg, 0.10 mmol) with LiAlH4 (5.7 mg 0.15 mmol) furnished the product (10 mg, 24%) after chromatography.

Sources & evidence

ORD record
ord-2681eac091f24b6d9eb0646017251629
Source dataset
uspto-grants-2009_03
Patent number
US07511047B2

Reaction notes

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