Methanol → HCID 68894574, compound

HRID 1787496Notes

Reaction equation

HRID 1787496 reaction equation
[C:1]1([C:7]2[C:8]3[C:9](=[N:14][O:15][CH:16]=3)[C:10](=[O:13])[NH:11][N:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17][OH:18]>N1CCCCC1>[CH3:17][O:18][C:16]([C:8]1[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[N:12][NH:11][C:10](=[O:13])[C:9]=1[NH2:14])=[O:15]

Participants

4

Reactant 2

HCID 887MethanolHCID 33029Isoxazolo(3,4-d)pyridazin-7(6H)-one, 4-phenyl-

Product 1

HCID 68894574HCID 68894574, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 8082PiperidineSolvent

Procedure

To a stirred solution of 4-phenyl-6H-isoxazolo[3,4-d]pyridazin-7-one (330 mg, 1.55 mmol) (V. Dal Piaz et al., Heterocycles, 1991, 32(6), 1173) in methanol (15 mL), piperidine was added (0.4 mL) and the mixture was refluxed for 1 h. Solvent was removed under reduced pressure and the residue was treated with water. The solid thus formed was isolated by filtration and dried to yield the title product (70% yield).

Workup

  1. temperaturethe mixture was refluxed for 1 h
  2. customSolvent was removed under reduced pressure
  3. additionthe residue was treated with water
  4. customThe solid thus formed
  5. customwas isolated by filtration
  6. customdried

Sources & evidence

ORD record
ord-5cb58cc27a3a487c980315a799021920
Source dataset
uspto-grants-2009_03
Patent number
US07511038B2

Reaction notes

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