Hydrochloric Acid → HCID 178486502, compound

HRID 1787538Notes

Reaction equation

HRID 1787538 reaction equation
[CH3:1][O:2][C:3]1[C:4]([O:25][CH3:26])=[CH:5][C:6]2[C:7]3[N:8]([CH2:22][CH2:23][N:24]=3)[C:9](/[CH:13]=[C:14](/[C:16]3[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=3)\[OH:15])=[N:10][C:11]=2[CH:12]=1.[ClH:27]>O1CCOCC1>[ClH:27].[CH3:1][O:2][C:3]1[C:4]([O:25][CH3:26])=[CH:5][C:6]2[C:7]3[N:8]([CH2:22][CH2:23][N:24]=3)[C:9](/[CH:13]=[C:14](/[C:16]3[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=3)\[OH:15])=[N:10][C:11]=2[CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178486501HCID 178486501, compound

Product 1

HCID 178486502HCID 178486502, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of (Z-2-(8,9-dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-1-(3-pyridinyl)ethenol (16.8 mg, 0.05 mmol)) in dioxane (15 ml) at room temperature was added aqueous 6N HCl solution (0.05 ml). After being stirred for 30 minutes, the mixture was dried under reduced pressure to give (Z)-2-(8,9-dimethoxy-2,3-di-hydroimidazo[1,2-c]quinazolin-5-yl)-1-(3-pyridinyl)ethenol hydrochloride (18.5 mg, quantitative) as a yellow solid.

Workup

  1. customthe mixture was dried under reduced pressure

Sources & evidence

ORD record
ord-66d5e11f577345e3a22171496eb71fe6
Source dataset
uspto-grants-2009_03
Patent number
US07511041B2

Reaction notes

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