Hydrochloric Acid → HCID 178493846, compound

HRID 1787547Notes

Reaction equation

HRID 1787547 reaction equation
[OH:1][C:2]([C:26]1[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=1)=[CH:3][C:4]1[N:13]2[CH2:14][CH2:15][N:16]=[C:12]2[C:11]2[CH:10]=[CH:9][C:8]([O:17][CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[C:7]([O:24][CH3:25])[C:6]=2[N:5]=1.[ClH:32]>O1CCOCC1.C(OCC)C>[ClH:32].[OH:1][C:2]([C:26]1[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=1)=[CH:3][C:4]1[N:13]2[CH2:14][CH2:15][N:16]=[C:12]2[C:11]2[CH:10]=[CH:9][C:8]([O:17][CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[C:7]([O:24][CH3:25])[C:6]=2[N:5]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178493845HCID 178493845, compound

Product 1

HCID 178493846HCID 178493846, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Procedure

A mixture of 4-{[5-(2-hydroxy-2-pyridin-3-ylvinyl)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-8-yl]oxy}butanoic acid (Example 1-6) 4.0 mg (9.5 micromol) in 4N HCl in 1,4-dioxane 2.0 mL was stirred at room temperature for 2 hours. The reaction mixture was diluted with diethyl ether. The precipitate was collected to give the title compound 4.00 mg as a yellow solid. Yield 92.0%.

Workup

  1. customThe precipitate was collected

Sources & evidence

ORD record
ord-c7c40b8ba8c245a6a51c6c57d6b6b973
Source dataset
uspto-grants-2009_03
Patent number
US07511041B2

Reaction notes

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