Hydrochloric Acid → 6-acetamido-N-(8-morpholin-4-yl-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyridine-3-carboxamide;hydrochloride

HRID 1787558Notes

Reaction equation

HRID 1787558 reaction equation
[C:1]([NH:4][C:5]1[CH:32]=[CH:31][C:8]([C:9]([NH:11][C:12]2[N:21]3[CH2:22][CH2:23][N:24]=[C:20]3[C:19]3[CH:18]=[CH:17][C:16]([N:25]4[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)=[CH:15][C:14]=3[N:13]=2)=[O:10])=[CH:7][N:6]=1)(=[O:3])[CH3:2].[ClH:33]>O1CCOCC1>[ClH:33].[C:1]([NH:4][C:5]1[CH:32]=[CH:31][C:8]([C:9]([NH:11][C:12]2[N:21]3[CH2:22][CH2:23][N:24]=[C:20]3[C:19]3[CH:18]=[CH:17][C:16]([N:25]4[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)=[CH:15][C:14]=3[N:13]=2)=[O:10])=[CH:7][N:6]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178474220HCID 178474220, compound

Product 1

HCID 1784742216-acetamido-N-(8-morpholin-4-yl-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyridine-3-carboxamide;hydrochlorideYield 78%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a mixture of 6-(acetamido)-N-[8-(morpholin-4-yl)-2,3-dihydroimidazo[1,2-c]-quinazolin-5-yl]nicotinamide (Example 2-3) 20.0 mg (0.046 mmol) in 1,4-dioxane 1.5 mL was added 4N HCl in 1,4-dioxane 0.5 mL and stirred at room temperature for 40 minutes. The precipitate was collected and washed with diethyl ether to give the title compound 17.0 mg as yellow solid. Yield 78%.

Workup

  1. customThe precipitate was collected
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-2e64b0ca6e1142e8a6da646352088218
Source dataset
uspto-grants-2009_03
Patent number
US07511041B2

Reaction notes

Loading…