Hydrochloric Acid → HCID 136385123, compound

HRID 1787564Notes

Reaction equation

HRID 1787564 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[C:13]=1[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=[C:5]2/[CH:14]=[C:15](/[C:17]1[S:18][CH:19]=[CH:20][CH:21]=1)\[OH:16].[ClH:22]>C(Cl)(Cl)Cl.O1CCOCC1.C(OCC)C>[ClH:22].[N:1]1[CH:2]=[CH:3][N:4]2[C:13]=1[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=[C:5]2/[CH:14]=[C:15](/[C:17]1[S:18][CH:19]=[CH:20][CH:21]=1)\[OH:16]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 136044398HCID 136044398, compound

Product 1

HCID 136385123HCID 136385123, compound

Reagents, catalysts & solvents 3

HCID 3283Diethyl EtherSolventHCID 6212ChloroformSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of (Z-2-imidazo[1,2-c]quinazolin-5-yl-1-(2-thienyl)ethenol (0.06 g, 0.07 mmol) in chloroform (1.0 ml) was added a 4N solution of HCl in 1,4-dioxane (0.5 ml). The mixture was diluted with ethyl ether, and the resulting precipitate was collected by filtration, washed with ethyl ether, and dried under reduced pressure to give (Z)-2-imidazo[1,2-c]quinazolin-5-yl-1-(2-thienyl)ethenol hydrochloride (0.07 g, quantative) as a yellow solid.

Workup

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed with ethyl ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-acb5f2eb7f7347b5a7b2e2062208c006
Source dataset
uspto-grants-2009_03
Patent number
US07511041B2

Reaction notes

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