Water → 677341-61-6

HRID 1787565Notes

Reaction equation

HRID 1787565 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=1[NH2:8].[N:13]#[C:14][Br:15].O>CO>[BrH:15].[N:1]1[CH:5]=[CH:4][N:3]2[C:2]=1[C:6]1[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=1[N:8]=[C:14]2[NH2:13]

Participants

5

Reactant 3

HCID 962WaterHCID 10476Cyanogen BromideHCID 156205002-(1H-Imidazol-2-yl)aniline

Product 1

HCID 66594113677341-61-6Yield 61%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-(1H-imidazol-2-yl)aniline (0.06 g. 0.38 mmol) in methanol (3 ml) was added cyanogen bromide (0.05 g, 0.45 mmol). The resulting mixture was stirred at room temperature overnight. The reaction mixture was poured into water, and the resulting precipitate was collected by filtration, washed with acetone, and dried under reduced pressure to give imidazo[1,2-c]quinazolin-5-amine hydrobromide (0.06 g, 61% yield) as a white solid.

Workup

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed with acetone
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-011aa2a49c6944ec819f2658840ab803
Source dataset
uspto-grants-2009_03
Patent number
US07511041B2

Reaction notes

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