反应详情

Add potassium carbonate (40 mg, 0.29 mmol) to a solution of 1-benzenesulfonyl-3-[2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-1H-pyrrolo[2,3-c]pyridine (Example 12, Part A; 16 mg, 0.036 mmol) in methanol (3 mL). Reflux the reaction mixture overnight (15 h). Concentrate the mixture in vacuo and purify by silica gel chromatography, using the appropriate mixture of methylene chloride, chloroform, methanol, and concentrated aqueous ammonium hydroxide, to provide 7 mg (64%) of the title compound as a tan solid. MS (ES) m/z=302 (M+H).

1. temperatureReflux the reaction mixture overnight (15 h)
2. concentrationConcentrate the mixture in vacuo
3. custompurify by silica gel chromatography
4. additionthe appropriate mixture of methylene chloride, chloroform, methanol, and concentrated aqueous ammonium hydroxide