2-Amino-5-fluoropyridine → (5-Fluoro-pyridin-2-yl)-(2-methyl-[1,7]naphthyridin-8-yl)-amine

HRID 1787600Notes

Reaction equation

HRID 1787600 reaction equation
Cl[C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][N:15]=1>>[F:20][C:17]1[CH:18]=[CH:19][C:14]([NH:13][C:2]2[N:3]=[CH:4][CH:5]=[C:6]3[C:11]=2[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]3)=[N:15][CH:16]=1

Participants

3

Reactant 2

HCID 27377012-Amino-5-fluoropyridineHCID 576003498-Chloro-2-methyl-1,7-naphthyridine

Product 1

HCID 16118554(5-Fluoro-pyridin-2-yl)-(2-methyl-[1,7]naphthyridin-8-yl)-amine

Procedure

The title compound, MS: m/e=255.3 (M+H+), was prepared in accordance with the general method of example 1 from 8-chloro-2-methyl-[1,7]naphthyridine (Example E) and 2-amino-5-fluoropyridine.

Sources & evidence

ORD record
ord-f3d4c0c1d8ae449d87cc74af3b913da1
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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