2-Methyl-1,3-thiazol-4-amine → (2-Methyl-[1,7]naphthyridin-8-yl)-(2-methyl-thiazol-4-yl)-amine

HRID 1787604Notes

Reaction equation

HRID 1787604 reaction equation
Cl[C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[NH2:13][C:14]1[N:15]=[C:16]([CH3:19])[S:17][CH:18]=1>>[CH3:12][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[C:2]([NH:13][C:14]3[N:15]=[C:16]([CH3:19])[S:17][CH:18]=3)[N:3]=[CH:4][CH:5]=2)[N:10]=1

Participants

3

Reactant 2

HCID 147727002-Methyl-1,3-thiazol-4-amineHCID 576003498-Chloro-2-methyl-1,7-naphthyridine

Product 1

HCID 16118557(2-Methyl-[1,7]naphthyridin-8-yl)-(2-methyl-thiazol-4-yl)-amine

Procedure

The title compound, MS: m/e=257.2 (M+H+), was prepared in accordance with the general method of example 1 from 8-chloro-2-methyl-[1,7]naphthyridine (Example E) and 4-amino-2-methylthiazole (Example F).

Sources & evidence

ORD record
ord-8ed477f8a60747ec93439a256352e767
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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