2-Methyl-1,3-thiazol-4-amine → 2-Chloro-N-(2-methyl-4-thiazolyl)-1,7-naphthyridin-8-amine

HRID 1787606Notes

Reaction equation

HRID 1787606 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5](OS(C(F)(F)F)(=O)=O)[N:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:20][C:21]1[N:22]=[C:23]([CH3:26])[S:24][CH:25]=1>>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([NH:20][C:21]3[N:22]=[C:23]([CH3:26])[S:24][CH:25]=3)[N:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 147727002-Methyl-1,3-thiazol-4-amineHCID 57600353HCID 57600353, compound

Product 1

HCID 161186912-Chloro-N-(2-methyl-4-thiazolyl)-1,7-naphthyridin-8-amine

Procedure

The title compound, MS: m/e=277.0/279.1 (M+H+), was prepared in accordance with the general method of example 1 from trifluoro-methanesulfonic acid 2-chloro-[1,7]naphthyridin-8-yl ester (Example G) and 4-amino-2-methylthiazole (Example F).

Sources & evidence

ORD record
ord-f890bc82a5114a1087e119534befe52f
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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