2-Amino-4-methylthiazole → HCID 16118829, compound

HRID 1787609Notes

Reaction equation

HRID 1787609 reaction equation
Br[C:2]1[CH:11]=[N:10][C:9](Cl)=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[N:13]1[CH:18]=[C:17](B(O)O)[CH:16]=[N:15][CH:14]=1.[NH2:22][C:23]1[S:24][CH:25]=[C:26]([CH3:28])[N:27]=1>>[CH3:28][C:26]1[N:27]=[C:23]([NH:22][C:9]2[N:10]=[CH:11][C:2]([C:17]3[CH:18]=[N:13][CH:14]=[N:15][CH:16]=3)=[C:3]3[C:8]=2[N:7]=[CH:6][CH:5]=[CH:4]3)[S:24][CH:25]=1

Participants

4

Reactant 3

HCID 741432-Amino-4-methylthiazoleHCID 2795193(Pyrimidin-5-yl)boronic acidHCID 422813655-Bromo-8-chloro-1,7-naphthyridine

Product 1

HCID 16118829HCID 16118829, compound

Procedure

The title compound, MS: m/e=321.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 5-bromo-8-chloro-[1,7]naphthyridine (Example H), 5-pyrimidineboronic acid and 2-amino-4-methylthiazole.

Sources & evidence

ORD record
ord-126026fb034148ac9862a5569f986898
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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