2-Chloropyridin-4-amine → (2-Chloro-pyridin-4-yl)-(2-methyl-5-pyridin-3-yl-[1,7]naphthyridin-8-yl)-amine

HRID 1787617Notes

Reaction equation

HRID 1787617 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5](I)=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[N:14]1[CH:19]=[CH:18][CH:17]=[C:16](B(O)O)[CH:15]=1.[Cl:23][C:24]1[CH:29]=[C:28]([NH2:30])[CH:27]=[CH:26][N:25]=1>>[Cl:23][C:24]1[CH:29]=[C:28]([NH:30][C:2]2[N:3]=[CH:4][C:5]([C:16]3[CH:15]=[N:14][CH:19]=[CH:18][CH:17]=3)=[C:6]3[C:11]=2[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]3)[CH:27]=[CH:26][N:25]=1

Participants

4

Reactant 3

HCID 844322-Chloropyridin-4-amineHCID 27343783-Pyridinylboronic acidHCID 576003528-Chloro-5-iodo-2-methyl-[1,7]naphthyridine

Product 1

HCID 16118962(2-Chloro-pyridin-4-yl)-(2-methyl-5-pyridin-3-yl-[1,7]naphthyridin-8-yl)-amine

Procedure

The title compound, MS: m/e=348.2/350.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), 3-pyridineboronic acid and 2-chloro-4-aminopyridine.

Sources & evidence

ORD record
ord-2a347eff16674c3f923f542f868c5fee
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

Loading…