2-Amino-4-methylthiazole → [5-(3-Methoxy-phenyl)-2-methyl-[1,7]naphthyridin-8-yl]-(4-methyl-thiazol-2-yl)-amine

HRID 1787618Notes

Reaction equation

HRID 1787618 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5](I)=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[CH3:14][O:15][C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[CH:20][CH:21]=1.[NH2:25][C:26]1[S:27][CH:28]=[C:29]([CH3:31])[N:30]=1>>[CH3:14][O:15][C:16]1[CH:17]=[C:18]([C:5]2[CH:4]=[N:3][C:2]([NH:25][C:26]3[S:27][CH:28]=[C:29]([CH3:31])[N:30]=3)=[C:11]3[C:6]=2[CH:7]=[CH:8][C:9]([CH3:12])=[N:10]3)[CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 3

HCID 741432-Amino-4-methylthiazoleHCID 2734370(3-Methoxyphenyl)boronic acidHCID 576003528-Chloro-5-iodo-2-methyl-[1,7]naphthyridine

Product 1

HCID 16117450[5-(3-Methoxy-phenyl)-2-methyl-[1,7]naphthyridin-8-yl]-(4-methyl-thiazol-2-yl)-amine

Procedure

The title compound, MS: m/e=363.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), 3-methoxyphenylboronic acid and 2-amino-4-methylthiazole.

Sources & evidence

ORD record
ord-a407114103ed48cda5d83d1ca95f927a
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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