2-Amino-4-methylthiazole → (4-Methyl-thiazol-2-yl)-[2-methyl-5-(3-trifluoromethyl-phenyl)-[1,7]naphthyridin-8-yl]-amine

HRID 1787619Notes

Reaction equation

HRID 1787619 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5](I)=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[F:14][C:15]([F:26])([F:25])[C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[CH:20][CH:21]=1.[NH2:27][C:28]1[S:29][CH:30]=[C:31]([CH3:33])[N:32]=1>>[CH3:33][C:31]1[N:32]=[C:28]([NH:27][C:2]2[N:3]=[CH:4][C:5]([C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([C:15]([F:26])([F:25])[F:14])[CH:21]=3)=[C:6]3[C:11]=2[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]3)[S:29][CH:30]=1

Participants

4

Reactant 3

HCID 741432-Amino-4-methylthiazoleHCID 27343883-(Trifluoromethyl)phenylboronic acidHCID 576003528-Chloro-5-iodo-2-methyl-[1,7]naphthyridine

Product 1

HCID 16117451(4-Methyl-thiazol-2-yl)-[2-methyl-5-(3-trifluoromethyl-phenyl)-[1,7]naphthyridin-8-yl]-amine

Procedure

The title compound, MS: m/e=401.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), 3-(trifluoromethyl)phenylboronic acid and 2-amino-4-methylthiazole.

Sources & evidence

ORD record
ord-c178662875c94cb994b137464d585260
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

Loading…