2-Amino-4-methylthiazole → HCID 16117452, compound

HRID 1787626Notes

Reaction equation

HRID 1787626 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5](I)=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[CH3:14][S:15]([C:18]1[CH:19]=[C:20](B(O)O)[CH:21]=[CH:22][CH:23]=1)(=[O:17])=[O:16].[NH2:27][C:28]1[S:29][CH:30]=[C:31]([CH3:33])[N:32]=1>>[CH3:14][S:15]([C:18]1[CH:19]=[C:20]([C:5]2[CH:4]=[N:3][C:2]([NH:27][C:28]3[S:29][CH:30]=[C:31]([CH3:33])[N:32]=3)=[C:11]3[C:6]=2[CH:7]=[CH:8][C:9]([CH3:12])=[N:10]3)[CH:21]=[CH:22][CH:23]=1)(=[O:17])=[O:16]

Participants

4

Reactant 3

HCID 741432-Amino-4-methylthiazoleHCID 27735423-(Methylsulfonyl)phenylboronic acidHCID 576003528-Chloro-5-iodo-2-methyl-[1,7]naphthyridine

Product 1

HCID 16117452HCID 16117452, compound

Procedure

The title compound, MS: m/e=411.1 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), (3-methylsulfonylphenyl)boronic acid and 2-amino-4-methylthiazole.

Sources & evidence

ORD record
ord-fd215a531ec049e38574871df42012a0
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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