2-Amino-4-methylthiazole → HCID 16116932, compound

HRID 1787629Notes

Reaction equation

HRID 1787629 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5](I)=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[CH3:14][C:15]1[CH:20]=[CH:19][N:18]=[CH:17][C:16]=1B(O)O.[NH2:24][C:25]1[S:26][CH:27]=[C:28]([CH3:30])[N:29]=1>>[CH3:12][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[C:2]([NH:24][C:25]3[S:26][CH:27]=[C:28]([CH3:30])[N:29]=3)[N:3]=[CH:4][C:5]=2[C:16]2[CH:17]=[N:18][CH:19]=[CH:20][C:15]=2[CH3:14])[N:10]=1

Participants

4

Reactant 3

HCID 741432-Amino-4-methylthiazoleHCID 27627114-Methylpyridine-3-Boronic AcidHCID 576003528-Chloro-5-iodo-2-methyl-[1,7]naphthyridine

Product 1

HCID 16116932HCID 16116932, compound

Procedure

The title compound, MS: m/e=348.1 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), 4-methylpyridine-3-boronic acid and 2-amino-4-methylthiazole.

Sources & evidence

ORD record
ord-f21362cf2e6849859ccf39fb6c5fcbb1
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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