2-Amino-4-methylthiazole → HCID 16117054, compound

HRID 1787632Notes

Reaction equation

HRID 1787632 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5](I)=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[CH3:14][O:15][C:16]1[CH:17]=[N:18][CH:19]=[C:20](B2OC(C)(C)C(C)(C)O2)[CH:21]=1.[NH2:31][C:32]1[S:33][CH:34]=[C:35]([CH3:37])[N:36]=1>>[CH3:14][O:15][C:16]1[CH:21]=[C:20]([C:5]2[CH:4]=[N:3][C:2]([NH:31][C:32]3[S:33][CH:34]=[C:35]([CH3:37])[N:36]=3)=[C:11]3[C:6]=2[CH:7]=[CH:8][C:9]([CH3:12])=[N:10]3)[CH:19]=[N:18][CH:17]=1

Participants

4

Reactant 3

HCID 741432-Amino-4-methylthiazoleHCID 38661613-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridineHCID 576003528-Chloro-5-iodo-2-methyl-[1,7]naphthyridine

Product 1

HCID 16117054HCID 16117054, compound

Procedure

The title compound, MS: m/e=364.1 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), 3-methoxy-5-pyridineboronic acid pinacol ester and 2-amino-4-methylthiazole.

Sources & evidence

ORD record
ord-e6ab16a4655941c0aaf655306c68602f
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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