HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-methylthiazole → [2-Methyl-5-(3-methyl-pyridin-2-yl)-[1,7]naphthyridin-8-yl]-(4-methyl-thiazol-2-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-methylthiazole | HCID 74143 | — |
| Reactant | 3-Methyl-2-pyridineboronic acid | HCID 17750271 | — |
| Reactant | 8-Chloro-5-iodo-2-methyl-[1,7]naphthyridine | HCID 57600352 | — |
| Product | [2-Methyl-5-(3-methyl-pyridin-2-yl)-[1,7]naphthyridin-8-yl]-(4-methyl-thiazol-2-yl)-amine | HCID 16117055 | — |
Reaction Steps
The title compound, MS: m/e=348.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), 3-methylpyridine-2-boronic acid and 2-amino-4-methylthiazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511055B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-e4c0d1a6065b4a09a196a771daeb1cdd |
| Source note | uspto-grants-2009_03 |