2-Amino-4-methylthiazole → [2-Methyl-5-(3-methyl-pyridin-2-yl)-[1,7]naphthyridin-8-yl]-(4-methyl-thiazol-2-yl)-amine

HRID 1787633Notes

Reaction equation

HRID 1787633 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5](I)=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[CH3:14][C:15]1[C:16](B(O)O)=[N:17][CH:18]=[CH:19][CH:20]=1.[NH2:24][C:25]1[S:26][CH:27]=[C:28]([CH3:30])[N:29]=1>>[CH3:12][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[C:2]([NH:24][C:25]3[S:26][CH:27]=[C:28]([CH3:30])[N:29]=3)[N:3]=[CH:4][C:5]=2[C:16]2[C:15]([CH3:14])=[CH:20][CH:19]=[CH:18][N:17]=2)[N:10]=1

Participants

4

Reactant 3

HCID 741432-Amino-4-methylthiazoleHCID 177502713-Methyl-2-pyridineboronic acidHCID 576003528-Chloro-5-iodo-2-methyl-[1,7]naphthyridine

Product 1

HCID 16117055[2-Methyl-5-(3-methyl-pyridin-2-yl)-[1,7]naphthyridin-8-yl]-(4-methyl-thiazol-2-yl)-amine

Procedure

The title compound, MS: m/e=348.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), 3-methylpyridine-2-boronic acid and 2-amino-4-methylthiazole.

Sources & evidence

ORD record
ord-e4c0d1a6065b4a09a196a771daeb1cdd
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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