2-Amino-4-methylthiazole → HCID 16117312, compound

HRID 1787647Notes

Reaction equation

HRID 1787647 reaction equation
Cl[C:2]1[C:11]2[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7][C:6]=2[C:5](B(O)O)=[CH:4][N:3]=1.Br[C:17]1[S:18][CH:19]=[CH:20][N:21]=1.[NH2:22][C:23]1[S:24][CH:25]=[C:26]([CH3:28])[N:27]=1>>[CH3:28][C:26]1[N:27]=[C:23]([NH:22][C:2]2[N:3]=[CH:4][C:5]([C:17]3[S:18][CH:19]=[CH:20][N:21]=3)=[C:6]3[C:11]=2[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]3)[S:24][CH:25]=1

Participants

4

Reactant 3

HCID 741432-Amino-4-methylthiazoleHCID 764302-BromothiazoleHCID 57416446(8-Chloro-2-methyl-1,7-naphthyridin-5-yl)boronic acid

Product 1

HCID 16117312HCID 16117312, compound

Procedure

The title compound, MS: m/e=340.0 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-2-methyl-[1,7]naphthyridine-5-boronic acid (Example L), 2-bromothiazole and 2-amino-4-methylthiazole.

Sources & evidence

ORD record
ord-eacdd362c3974108bf482f341dff78bb
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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