2-Amino-4-methylthiazole → HCID 16117313, compound

HRID 1787648Notes

Reaction equation

HRID 1787648 reaction equation
Cl[C:2]1[C:11]2[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7][C:6]=2[C:5](B(O)O)=[CH:4][N:3]=1.Br[C:17]1[N:21]([CH3:22])[CH:20]=[N:19][CH:18]=1.[NH2:23][C:24]1[S:25][CH:26]=[C:27]([CH3:29])[N:28]=1>>[CH3:12][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[C:2]([NH:23][C:24]3[S:25][CH:26]=[C:27]([CH3:29])[N:28]=3)[N:3]=[CH:4][C:5]=2[C:17]2[N:21]([CH3:22])[CH:20]=[N:19][CH:18]=2)[N:10]=1

Participants

4

Reactant 3

HCID 741432-Amino-4-methylthiazoleHCID 15152585-Bromo-1-methyl-1H-imidazoleHCID 57416446(8-Chloro-2-methyl-1,7-naphthyridin-5-yl)boronic acid

Product 1

HCID 16117313HCID 16117313, compound

Procedure

The title compound, MS: m/e=337.3 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-2-methyl-[1,7]naphthyridine-5-boronic acid (Example L), 5-bromo-1-methyl-1H-imidazole and 2-amino-4-methylthiazole.

Sources & evidence

ORD record
ord-3d95738aac534a398da04c342b73eacb
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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