2-Amino-4-methylthiazole → HCID 16117448, compound

HRID 1787656Notes

Reaction equation

HRID 1787656 reaction equation
Cl[C:2]1[C:11]2[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7][C:6]=2[C:5](B(O)O)=[CH:4][N:3]=1.I[C:17]1[CH:22]=[N:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[N:18]=1.[NH2:27][C:28]1[S:29][CH:30]=[C:31]([CH3:33])[N:32]=1>>[CH3:33][C:31]1[N:32]=[C:28]([NH:27][C:2]2[N:3]=[CH:4][C:5]([C:17]3[CH:22]=[N:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[N:18]=3)=[C:6]3[C:11]=2[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]3)[S:29][CH:30]=1

Participants

4

Reactant 3

HCID 741432-Amino-4-methylthiazoleHCID 200966762-Iodo-6-(trifluoromethyl)pyrazineHCID 57416446(8-Chloro-2-methyl-1,7-naphthyridin-5-yl)boronic acid

Product 1

HCID 16117448HCID 16117448, compound

Procedure

The title compound, MS: m/e=403.3 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-2-methyl-[1,7]naphthyridine-5-boronic acid (Example L), 2-iodo-6-trifluoromethyl-pyrazine (Example O) and 2-amino-4-methylthiazole.

Sources & evidence

ORD record
ord-1bdcfb67bcbc4b75ae2faabb8da8f78a
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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