HCID 57599588, compound → HCID 57599585, compound

HRID 1787703Notes

Reaction equation

HRID 1787703 reaction equation
[OH:1][CH:2]([CH:12]1[CH2:17][CH2:16][N:15](CC2C=CC=CC=2)[CH2:14][CH2:13]1)[CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8]>[OH-].[OH-].[Pd+2]>[OH:1][CH:2]([CH:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1)[CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8]

Participants

3

Reactant 1

HCID 57599588HCID 57599588, compound

Product 1

HCID 57599585HCID 57599585, compound

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

A solution of 1,1-dimethylethyl {2-hydroxy-2-[1-(phenylmethyl)-4-piperidinyl]ethyl}carbamate (2 g, 5.97 mmol) and Pd(OH)2 (1.2 g, 60 wt %) in ETOH (30 mL) was hydrogenated at 60 psi using a Parr Shaker. After 12 h, the solution was filtered through Celite® and concentrated affording the title compound as a yellow oil which was used directly without further purification: LCMS (ES) m/e 245 (M+H)+.

Workup

  1. filtrationthe solution was filtered through Celite®
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-6e154ecf8e6941e7824d1b43eee168f3
Source dataset
uspto-grants-2009_03
Patent number
US07511035B2

Reaction notes

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