HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 53237888, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Iodine | HCID 807 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | alpha-Methyl-3-nitrobenzenemethanol | HCID 223135 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 53237888 | HCID 53237888 | 90.6% |
Reaction Steps
5 g of 3-nitrophenylethanol, 9.4 g of triphenylphosphine and 3.1 g of imidazole are dissolved in 250 ml of THF, mixed in portions with 9.1 g of iodine and stirred for 15 hours at room temperature. The reaction mixture is mixed with ammonium chloride solution and extracted with dichloromethane. The organic phase is washed in succession with sodium thiosulfate solution and water and dried on sodium sulfate. After purification by chromatography on silica gel, 7.51 g of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511059B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-62e1a56f9c2d4da692d9cff1587c1dbf |
| Source note | uspto-grants-2009_03 |